rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
• The frequencies of three CaP risk alleles (rs1447295 [8q24], P= 0.004; rs1571801 [9q33.2], P= 0.03; rs11228565 [11q13], P= 0.02) were significantly higher in men with 'unfavourable' pathological characteristics.
|
22077888 |
2012 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37-2.81], P<0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41-3.26], P<0.0001) with CaP.
|
23628314 |
2014 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We identified multiple SNPs in a 50-kb region (referred to as locus 1) that are in linkage disequilibrium with a previously reported risk-associated SNP at 8q24, rs1447295, but were more strongly associated with prostate cancer risk in our study population.
|
17925536 |
2007 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We demonstrate that trans-acting RNA molecules facilitating resistance to androgen depletion (RAD) in vitro and castration-resistant phenotype (CRP) in vivo of PC contain intergenic 8q24-locus SNP variants (rs1447295; rs16901979; rs6983267) that were recently linked with increased risk of PC.
|
22067658 |
2011 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We conclude that the A allele of rs1447295 is associated with a higher risk of prostate cancer regardless of tumor aggressiveness, suggesting that such a variant, or a variant in linkage disequilibrium with it, plays a role early in prostate carcinogenesis.
|
17372260 |
2007 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Three prostate cancer susceptibility single-nucleotide polymorphisms (rs1447295 at 8q24, rs7920517 and rs10993994 at 10q11) were associated with prostate-specific antigen recurrence (P < 0.02).
|
19900942 |
2009 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men.
|
19428064 |
2009 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These results further confirm the importance of these two polymorphic variants (rs1447295 and DG8S737) as risk factors for PC.
|
17409399 |
2007 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Therefore, this meta-analysis demonstrated that 8q24 polymorphisms (rs6983267 T>G, rs1447295 C>A, rs16901979 C>A, rs6983561 A>C and rs10090154 C>T) were associated with the susceptibility to PCa, which held the potential biomarkers for PCa risk.
|
29158792 |
2017 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
There was a tendency towards significantly increased risk for SNPs rs1447295 and rs6983267 in men with early-onset prostate cancer.
|
21557270 |
2011 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
There are strong association between rs1447295 polymorphism and prostate cancer susceptibility in different ethnic groups and different prostate cancer stage, suggesting that rs1447295 might serve as a reliable biomarker for prostate cancer diagnosis.
|
28978014 |
2017 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates.
|
24377597 |
2014 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The cumulative effects test of risk alleles (rs rs1983891, rs339331, rs16901966, rs1447295 and rs10090154) showed an increasing risk to PCa in a frequency-dependent manner (ptrend=0.001), and men with more than 3 risk alleles had the most significant susceptibility to PCa (OR=1.99, p=0.001), compared with those who had one risk allele (OR=1.17, p=0.486).
|
26537068 |
2016 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27).
|
19602258 |
2009 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The A allele at SNP rs1447295 was associated with the incidence of prostate cancer.
|
22583965 |
2012 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs1447295 A allele was associated with susceptibility to PC (PC vs. non-PC: P = 0.041; OR, 1.28; 95%CI = 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, P = 0.013; OR, 1.43; 95%CI = 1.08-1.90).
|
18726982 |
2008 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs1447295 marker was strongly associated with prostate cancer among Caucasians (P = 1.23 x 10(-13)).
|
17409400 |
2007 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737.
|
17416775 |
2007 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, there was a positive association between carriers of the allele A of rs1447295 and prostate cancer risk [odds ratio (OR), 1.60; 95% confidence interval (95% CI), 1.01-2.52] but no significant association with carriers of alleles A of rs16901979 and allele G of rs6983267.
|
18768513 |
2008 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results corroborate previous reports of 8q24 as a prostate cancer susceptibility locus and provide evidence for rs1447295 as a potentially important genetic marker.
|
18625567 |
2009 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Interestingly, the effect of rs1447295 on PCa risk was observed among Caucasians and Asians, but not Africa-Americans.
|
26159557 |
2015 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In particular, both homozygous AA and heterozygous CA genotypes of rs16901979, as well as the AA and CA genotypes of rs1447295, were associated with the risk of prostate cancer.
|
30061842 |
2018 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the relationship between the rs1447295 and DG8S737 polymorphic variants on chromosome 8q24 and prostate cancer risk is seen in the Polish population to a similar degree as it has been observed elsewhere.
|
19952762 |
2010 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
rs1447295
|
|
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
For northern Chinese men rs16901966, rs1447295, rs11986220 and rs10090154 at 8q24 (region 1, region 2) are associated with prostate cancer and prostate cancer related clinical covariates.
|
22099997 |
2012 |